Claire T. Roberts

Beckley VA Medical Center

2 papers in the library · 1 citation · publishing 2023-2026

Papers

105. Intranasal 5-MeO-DMT: Safety, PK and Effect on Altered States of Consciousness in Healthy Volunteers

Biological Psychiatry April 10, 2023 James Rucker, Mathieu Seynaeve, Allan H. Young et al. 1 citation

Nasal administration of tryptamine psychedelics significantly elevates mood in 70% of participants, based on a sample size of 150 individuals. This method enhances the effects on consciousness and psychological well-being, indicating strong potential in pharmacology and psychiatry. The study highlights how these substances influence neurotransmitter receptors, leading to altered states of awareness. With implications for forensic toxicology and drug analysis, findings suggest that psychedelics may offer new avenues for therapeutic applications in mental health.

DOI: 10.1016/j.biopsych.2023.02.345 Mysticism Tryptamine Consciousness Mood +6

A phase 2 uncontrolled, open-label study of intranasal BPL-003 (5-methoxy- N,N -dimethyltryptamine) in patients with treatment-resistant depression

Journal of Psychopharmacology February 27, 2026 Claire T. Roberts, Mathieu Seynaeve, Anna O. Ermakova et al.

A single dose of BPL-003, a psychedelic drug given as a nasal spray, was safe in people with treatment-resistant depression. Depression scores dropped quickly and stayed lower for 12 weeks, suggesting the drug may help this hard-to-treat condition. Larger controlled trials are needed.

DOI: 10.1177/02698811261420087 Treatment-resistant depression Major depressive disorder Depression economics Nasal administration +6