It’s Tea Time: Interference of Ayahuasca Brew on Discriminative Learning in Zebrafish
Frontiers in Behavioral Neuroscience August 27, 2018 Bruno Lobão‐soares, Paulianny Eduardo-Da-Silva, Hugo Amarilha et al. 15 citations
Ayahuasca, a psychoactive brew containing β-carbolines and DMT, impairs memory and locomotion in zebrafish after chronic (13-day) exposure. In a one-trial object discrimination task, adult zebrafish exposed chronically to 0.1 or 0.5 ml/L ayahuasca showed worse discriminative performance and altered locomotion compared to controls, while acute (single) exposure did not affect memory but the higher concentration reduced locomotion. The findings suggest that chronic ayahuasca use negatively affects mnemonic parameters, reinforcing the zebrafish as a model for psychedelic drug screening.