Detection and Quantification of Psychoactive N,N-Dimethyltryptamine in Ayahuasca Brews by Ambient Ionization High-Resolution Mass Spectrometry
ACS Omega October 27, 2020 Megan I. Chambers, Meghan G. Appley, Cameron M. Longo et al. 17 citations
A rapid method using direct analysis in real time-high-resolution mass spectrometry (DART-HRMS) quantifies N,N-dimethyltryptamine (DMT) in ayahuasca brews without lengthy sample preparation. The technique also identifies the beverage by detecting secondary metabolites from its plant ingredients. Analysis of six ayahuasca brews made with different combinations of DMT- and harmala alkaloid-containing plants found DMT levels ranging from 45.7 to 230.5 mg/L, consistent with values from conventional methods.