In Vitro Study of the Bioavailability and Bioaccessibility of the Main Compounds Present in Ayahuasca Beverages
Molecules September 13, 2021 Joana Gonçalves, Miguel Castilho, Tiago Rosado et al. 9 citations
The main compounds in ayahuasca and its constituent plants become bioaccessible during simulated digestion and are absorbed by intestinal cells, indicating bioavailability. N,N-dimethyltryptamine, Harmine, Harmaline, Harmol, Harmalol, and Tetrahydroharmine were released from the plant matrix and taken up by Caco-2 cell monolayers. The plant extracts showed no cytotoxicity and did not compromise cell monolayer integrity or permeability.