Psychotherapeutic and neurobiological processes associated with ayahuasca’s mental health and wellbeing outcomes: a proposed model and implications for therapeutic use
February 14, 2022 Daniel Perkins, Simon Ruffell, Kimberley Day et al. 1 citation preprint
Ayahuasca, a psychoactive Amazonian brew containing harmala alkaloids and DMT, is increasingly used globally in traditional and neo-shamanic settings. This paper reviews existing literature and original data from the Global Ayahuasca Project, the largest cross-sectional study of ayahuasca drinkers, to propose a model of psychotherapeutic processes leading to mental health benefits. The model identifies five key processes: somatic effects; introspection and emotional processing; increased self-connection, value, and love; increased spiritual connection; and gaining insights and new perspectives. Differences from other classic psychedelics are noted, and the model aims to improve therapeutic use and optimize clinical treatment models.