5-MeO-DMT Use in Humans: A Scoping Review of Peer-Reviewed Research
January 8, 2026 Michael Esposito, Ana M Ortiz Bernal, Alan K. Davis et al. preprint
A scoping review of 33 peer-reviewed studies on 5-MeO-DMT use in humans found that most interventional studies (13 of 15) used inhalation administration, though dosages and dosing regimens varied widely. Common outcomes measured include cognition, depression, post-traumatic stress disorder, and anxiety. The review highlights large heterogeneity in study design, dosing, and support, and suggests future research should explore different routes of administration and include more neuroimaging, qualitative, and longitudinal data.