Molecular insights into GPCR mechanisms for drugs of abuse.
The Journal of biological chemistry September 1, 2023 Omar B Sanchez-Reyes, Gregory Zilberg, John D McCorvy et al. 10 citations
Opioids, cannabinoids, and psychedelics all act by binding to G protein-coupled receptors (GPCRs), which mediate their inebriating, lethal, and therapeutic effects. Recent structural studies reveal the molecular mechanisms of drugs like fentanyl, tetrahydrocannabinol, and lysergic acid diethylamide at their respective GPCR subtypes. These insights facilitate drug discovery, both for developing treatments to combat substance abuse and for harnessing the therapeutic potential of certain drugs.