Best practices for first psychedelic experiences: harm reduction advice from the psychedelic community
Figshare January 1, 2025 J. Kruger, Daniel, Mersereau, Gina, Sullivan, Ashley et al.
Most experienced psychedelic users recommend psilocybin for first-time experiences, favoring its moderate intensity, dose-dependent effects, precise dosing, and short duration. About half recommended cannabis, and a third recommended MDMA/MDA. Substances like ayahuasca, DMT, 5-MeO-DMT, and Salvia divinorum were not recommended due to intensity, health risks, and safety concerns. Participants advised against mixing psychedelics with alcohol, stimulants, antidepressants, and narcotics/opiates. Additional advice included embracing the experience, learning about the substance, and setting intentions. The findings suggest that harm-reduction resources can be developed from community-based crowdsourced recommendations.