Psychiatry Research
July 23, 2023
Otto Simonsson, Per Carlbring, Robin Carhart-Harris et al.
24 citations
In a meta-analysis of three psilocybin trials for depression involving 102 participants, clinically significant symptom worsening occurred for a minority of those receiving psilocybin or escitalopram (about 10%) and for a majority of those in the waitlist condition (63.6%). The psilocybin arm showed a lower likelihood of symptom worsening compared to waitlist and no difference compared to escitalopram. The authors note the limitation of a relatively small sample size.
Journal of Psychedelic Studies
April 2, 2024
M. Nordin, Jón Ingi Hlynsson, Jakob Håkansson Eklund et al.
17 citations
Interviews with eight psychedelic treatment providers revealed short-term negative effects including adverse reactions to psilocybin dosing sessions, problems in the therapeutic relationship, and difficult personal experiences. Long-term negative effects included destabilization of the client, trouble adjusting to life after treatment, complications in the treatment relationship, and other undesirable outcomes. The findings underscore the need for thorough pre-treatment assessment and post-treatment support to improve safety and clinical implementation.
Journal of evidence-based social work (2019)
January 1, 2024
Yi Ting Daphne Cheng, Kim Wan Daniel Young, Per Carlbring et al.
2 citations
A tailored mindfulness-based intervention (MBI) called REMIND 2.0 was compared with relaxation training (RT) in a small pilot trial with 28 people who have mental illness. MBI participants showed significant improvements in personal recovery, mindfulness, self-compassion, resilience, depression, positive and negative moods, quality of life, and general health immediately after the program, and most gains were maintained one month later. RT participants initially improved on secondary outcomes but then declined at follow-up, except for anxiety and stress. Participants found the MBI acceptable and relevant to personal recovery. The tailored MBI appears to be a potentially effective and feasible approach for supporting recovery in this population.
Social work
March 19, 2024
Daniel Kim-Wan Young, Per Carlbring, Daphne Yi-Ting Cheng et al.
1 citation
A guided online mindfulness-based intervention (iMBI) reduced anxiety and depressive symptoms with a large effect size and improved mindfulness with a moderate effect size among community residents in Hong Kong experiencing emotional distress during the COVID-19 pandemic. In a randomized controlled trial with 64 participants, those who received 16 online modules, weekly telephone counseling, and two half-day online workshops showed significantly greater improvements than a waitlist control group. The findings support the effectiveness of guided iMBI for emotional distress.