Department of Anesthesiology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, No. 136, Zhongshan Second Road, Chongging 400014, China; Chongqing Key Laboratory of Pediatrics, Chongqing, China.
2 papers in the library · 4 citations · publishing 2024-2025
Short-term mindfulness meditation training during the perioperative period reduces physiological and psychological stress in patients with gastrointestinal tumors. Patients who practiced daily meditation from admission through five days after surgery, compared to those receiving standard nursing care, had lower serum cortisol levels, reduced pain scores, shorter hospital stays, and less need for postoperative pain medication. Anxiety scores also trended lower in the meditation group, while mindfulness scores gradually increased. The findings suggest that brief mindfulness practice can help manage stress responses, improve recovery, and lower healthcare costs for this patient group.
Repeated esketamine exposure during early postnatal development in mice led to significant hippocampal injury, including downregulation of glutamatergic neuronal markers and persistent cognitive dysfunction in adolescence. These adverse outcomes were strongly associated with elevated expression of Kcnq2 in the hippocampus. Both pharmacological blockade and genetic knockdown of Kcnq2 mitigated the cognitive deficits. Mechanistically, activation of Kcnq2 drove dephosphorylation of key signaling molecules within the Akt1/GSK-3β pathway. The findings identify Kcnq2 as a novel therapeutic target for preventing anesthesia-related cognitive deficits in pediatric populations.