Electrophysiological Evidence of Serotonergic Impairment in Long-Term MDMA (“Ecstasy”) Users
American Journal of Psychiatry October 1, 2001 Rodney J. Croft, A. Klugman, Torsten Baldeweg et al. 100 citations
Serotonin (5-HT) dysfunction is present in people who use MDMA, is linked to the amount of MDMA they have consumed, and is not explained by cannabis use. The deficit relates to total lifetime MDMA consumption rather than how often the drug is taken, which argues against the idea that users are self-medicating a pre-existing condition. The findings are consistent with MDMA consumption causing serotonin impairment in humans.