Behavioral effects of MDMA (‘ecstasy’) on adult zebrafish
Behavioural Pharmacology April 8, 2011 Adam Stewart, Russell Riehl, Keith Wong et al. 66 citations
Acute exposure to high doses of MDMA (40-120 mg/l) reduces bottom swimming and immobility in zebrafish and impairs intrasession habituation at doses as low as 10 mg/l, while lower doses (0.25-10 mg/l) show no behavioral effects. MDMA also increases brain c-fos expression. These findings support the use of zebrafish as a model for screening hallucinogenic compounds.