Pill content, dose and resulting plasma concentrations of 3,4‐methylendioxymethamphetamine (MDMA) in recreational ‘ecstasy’ users
Addiction February 14, 2011 Kate Morefield, Michael Keane, Peter Felgate et al. 83 citations
Ecstasy pills in recreational settings often contain MDMA, but many also include other drugs like MDEA and methamphetamine. The amount of MDMA per pill varies widely, from 0 to 245 mg. Users typically consume between half a pill and five pills in a session, with total MDMA doses reaching up to 280 mg. Plasma concentrations of MDMA rise with the number of pills consumed and the cumulative dose. Taking multiple pills over several hours leads to sustained high MDMA levels in the blood, exposing the brain to the drug for longer than single-dose studies would suggest.