Biochemical effects of the monoamine neurotoxins DSP-4 and MDMA in specific brain regions of MAO-B-deficient mice
Synapse January 1, 2001 Francesco Fornai, Filippo Sean Giorgi, Marco Gesi et al. 54 citations
In mice lacking the enzyme monoamine oxidase B (MAO-B), the neurotoxin DSP-4 caused the same loss of norepinephrine in brain regions as it did in normal mice, indicating MAO-B is not involved in DSP-4 toxicity. For the neurotoxin MDMA (ecstasy), MAO-B deficiency prevented the serotonin depletion normally seen in wild-type mice but led to a more pronounced dopamine loss. These results suggest MAO-B plays opposite roles in MDMA-induced damage to dopamine and serotonin systems.