Dose-related effects of MDMA on psychomotor function and mood before, during, and after a night of sleep loss
Psychopharmacology January 18, 2010 Wendy M. Bosker, Kim P. C. Kuypers, Silke Conen et al. 45 citations
Sleep deprivation impairs psychomotor function, and the stimulant effects of MDMA are not sufficient to compensate for this impairment. In a randomized, double-blind, placebo-controlled crossover study, 16 recreational MDMA users received single doses of 25, 50, and 100 mg. While MDMA did not generally affect performance, the highest dose improved rapid information processing in the morning after administration. In the evening, MDMA increased subjective ratings of positive mood at every dose and subjective arousal at the highest dose, but these subjective effects were no longer present after a night of sleep loss.