Experience-dependent changes in temperature and behavioral activity induced by MDMA
Physiology & Behavior August 1, 2006 María E. Reverón, Esther Y. Maier, Christine L. Duvauchelle 23 citations
Rats that voluntarily self-administered moderate doses of MDMA (approximately 2.0–7.0 mg/kg/day) over 20 daily 2-hour sessions initially showed a drop in core body temperature after each session compared to baseline and to a control group that self-administered saline. Over time, this hypothermic response diminished, and by the final sessions core temperatures had risen above baseline. Locomotor activity during MDMA sessions was initially similar to saline levels but became significantly greater by day 8. These findings demonstrate that repeated voluntary MDMA intake leads to experience-dependent changes in temperature regulation and behavior.