MDMA‐evoked changes in [11C]raclopride and [11C]NMSP binding in living pig brain
Synapse July 14, 2004 Pedro Rosa‐neto, Albert Gjedde, Aage Kristian Olsen Alstrup et al. 39 citations
MDMA (Ecstasy) reduces the binding of two different radioligands to dopamine D2-like receptors in the striatum of living pigs, as measured by PET. The binding potential of [11C]raclopride fell by 35% at 45 minutes and 22% at 165 minutes after MDMA infusion, similar to changes caused by d-amphetamine. Unexpectedly, the binding of [11C]NMSP also decreased, by 30% in the first scan and 50% in the second, unlike its typical insensitivity to dopamine release. The simultaneous release of dopamine and serotonin by MDMA may explain the progressive decline in NMSP binding.