A New GC-MS Method for the Determination of Five Amphetamines in Human Hair
Journal of Analytical Toxicology March 1, 2005 J. L. Villamor, Ana María Bermejo, María Pilar Murias Fernández et al. 40 citations
A new gas chromatography-mass spectrometry method allows simultaneous identification and measurement of five amphetamine-type drugs in hair. Hair samples are hydrolyzed in sodium hydroxide, extracted with a solvent mixture, and derivatized before analysis. The method is accurate to within ±9% and precise, with coefficients of variation below 8%. Detection limits range from 0.007 to 0.045 ng/mg depending on the drug. In 24 positive hair specimens, average concentrations were 0.88 ng/mg for amphetamine, 10.14 ng/mg for methamphetamine, 1.30 ng/mg for MDA, and 8.87 ng/mg for MDMA; only one specimen contained MDEA at 0.84 ng/mg.