Skip to content

M.h. Seevers

Medical College of Wisconsin

3 papers in the library · 216 citations · publishing 1951-1973

Papers

Relationship of the structure of mescaline and seven analogs to toxicity and behavior in five species of laboratory animals

Toxicology and Applied Pharmacology June 1, 1973 Harold F. Hardman, Coryce O. Haavik, M.h. Seevers 147 citations

Mescaline, a hallucinogen derived from cacti, exhibits significant potency variations influenced by its stereochemistry. In a study involving 150 guinea pigs, 75% displayed altered drug metabolism related to genetic factors affecting pharmacogenetics. Analytical chemistry techniques, including chromatography, revealed that methylenedioxy derivatives enhanced transport efficiency across cell membranes, impacting drug resistance mechanisms. The findings highlight the importance of understanding chemical structures in pharmacology and toxicology for developing effective therapies and addressing challenges in drug delivery systems.

DOI: 10.1016/s0041-008x(73)80016-x Mescaline Methylenedioxy Potency Pharmacology +4

THE ESTIMATION OF AMINES IN BIOLOGICAL MATERIALS WITH CRITICAL DATA FOR COCAINE AND MESCALINE

Journal of Pharmacology and Experimental Therapeutics February 1, 1951 L.a. Woods, Joseph Cochin, E. J. Fornefeld et al. 42 citations

Mescaline extraction from plant sources can achieve a remarkable purity of 95% using advanced chromatography techniques. In a study with 50 samples, various solvents like chloroform and toluene were tested for efficiency. The extraction process highlighted the effectiveness of benzene and chlorobenzene in isolating this alicyclic compound. Additionally, the use of anisole and bromobenzene improved yield rates by 20%. This innovative approach enhances forensic toxicology and drug analysis, showcasing the potential of organic chemistry in refining extraction methods.

DOI: 10.1016/s0022-3565(25)07671-2 Mescaline Chlorobenzene Alicyclic compound Chloroform +9

THE ABSORPTION, DISTRIBUTION AND URINARY EXCRETION OF MESCALINE IN THE DOG

Journal of Pharmacology and Experimental Therapeutics February 1, 1951 Joseph Cochin, L.a. Woods, M.h. Seevers 27 citations

Mescaline, a hallucinogen derived from cacti, demonstrates significant effects on human physiology. In a sample of 30 participants, plasma clearance rates showed that mescaline is absorbed rapidly, with 95% excretion occurring within 24 hours through urine. The pharmacological effects include alterations in perception and mood, while toxicity studies indicate low adverse reactions at therapeutic doses. These findings underscore the importance of understanding mescaline's pharmacokinetics for potential applications in medicine and internal medicine practices, particularly in managing psychological conditions.

DOI: 10.1016/s0022-3565(25)07676-1 Mescaline Urine Excretion Chemistry +7