Involvement of 5-HT receptor subtypes in the discriminative stimulus properties of mescaline
European Journal of Pharmacology January 1, 1989 James B. Appel, Patrick M. Callahan 34 citations
Rats trained to distinguish mescaline (10 mg/kg) from saline showed that the mescaline cue generalized to high doses of the 5-HT2 agonists DOM, LSD, and psilocybin, while generalization to 5-HT1 agonists was unclear. The mescaline cue was blocked by high doses of 5-HT2 antagonists (ketanserin, LY-53857, pirenperone) but not by less selective serotonin (metergoline) or dopamine (SCH-23390, haloperidol) antagonists. These results suggest that 5-HT2 receptors are involved in the stimulus properties of mescaline.