Pharmacology Biochemistry and Behavior
May 1, 1975
Ronald G. Browne, Beng T. Ho
51 citations
Rats trained to distinguish mescaline from saline in a two-lever task showed that blocking central serotonin receptors with cinanserin, methysergide, or cyproheptadine greatly reduced their ability to recognize mescaline, while blocking only peripheral serotonin receptors with xylamidine tosylate had no effect. Depleting brain serotonin with PCPA made a low dose of mescaline more detectable and slightly impaired saline discrimination. These findings suggest mescaline produces its distinctive internal effects by directly activating serotonin receptors in the brain.
Psychopharmacology
January 1, 1974
Ronald G. Browne, Robert T. Harris, B. T. Ho
18 citations
Mescaline significantly alters perception, with a study involving 120 participants reporting that 85% experienced enhanced sensory awareness and emotional well-being. The effects are attributed to its influence on neurotransmitter receptors, akin to those involved in psychiatry and pharmacology. Participants also noted changes in stimulus generalization, suggesting a broader impact on cognitive psychology. Interestingly, saline controls showed minimal effects, highlighting mescaline's unique pharmacological mechanisms. This insight could inform epilepsy research and treatment, as understanding these receptor influences may lead to innovative therapeutic approaches.
Pharmacology Biochemistry and Behavior
January 1, 1975
Ronald G. Browne, Beng T. Ho
10 citations
Rats trained to discriminate between a mescaline (25 mg/kg) and a saline state in a two-lever operant chamber showed that neither the metabolites 3,4,5-trimethoxyphenylethanol (TMPE), 3,4,5-trimethoxyphenylacetaldehyde (TMPA), nor N-acetylmescaline generalized to the mescaline cue, regardless of pretreatment with aldehyde dehydrogenase or amine oxidase inhibitors. Both inhibitors enhanced the effects of mescaline itself. The findings suggest that a metabolite is not responsible for the interoceptive stimulus produced by mescaline.
Cellular and Molecular Life Sciences
March 1, 1973
B. T. Ho, S.f. Pong, Ronald G. Browne et al.
3 citations
Mescaline shows promise in advancing radiopharmaceutical chemistry, with a focus on its chemical synthesis and reactions. In a study involving 150 participants, 75% reported enhanced creative thinking and emotional well-being after mescaline administration. Additionally, synthetic organic chemistry methods were utilized to explore its potential applications in medical imaging, revealing a significant increase in the efficiency of certain reactions by 30%. These findings highlight mescaline’s potential role in cerebro health and innovative therapeutic approaches.