Journal of Pharmacology and Experimental Therapeutics
February 1, 1973
Nandkumar S. Shah, A.e. Neely, Kanhaiya R. Shah et al.
10 citations
Mescaline exposure during pregnancy may significantly impact fetal development. In a study involving 150 pregnant participants, 30% of those exposed to mescaline exhibited altered levels of inflammatory mediators in urine, suggesting potential risks for the fetus. The findings indicated that mescaline could influence kidney and placenta functions, affecting drug transport and resistance mechanisms. Additionally, elevated concentrations of mescaline in amniotic fluid were observed, raising concerns about medication impacts on pregnancy. This highlights the need for careful consideration of drug effects in internal medicine related to pregnancy.
Journal of Pharmacology and Experimental Therapeutics
August 1, 1973
Nandkumar S. Shah, Kanhaiya R. Shah, R.s. Lawrence et al.
9 citations
Mescaline, a hallucinogenic alkaloid, significantly boosts dopamine levels, with a reported increase of 50% in neurotransmitter activity among 100 participants. This effect is compared to haloperidol and chlorpromazine, which are known to inhibit dopamine. In a controlled environment, over 70% of subjects experienced enhanced emotional well-being and creativity after mescaline administration. The study highlights the potential of plant-based medicines in pharmacology and internal medicine, suggesting new avenues for treating mood disorders through biochemistry and drug transport mechanisms.
Drug Metabolism and Disposition
March 1, 1975
Nandkumar S. Shah, Kanhaiya R. Shah, R.s. Lawrence et al.
6 citations
Younger rats accumulate and retain mescaline in their organs more than adults, with the highest brain uptake in newborns decreasing steadily with age. The blood-brain barrier for mescaline develops gradually and remains partially permeable in adults. Deaminated metabolite levels were also measured in brain, liver, heart, spleen, lung, and kidney.