THE ANTIDOTAL ACTION OF SODIUM SUCCINATE IN THE MESCALINE PSYCHOSIS
American Journal of Psychiatry October 1, 1957 Ian H. Stevenson, Andrew J. Sanchez 8 citations
Sodium succinate had a definite antidotal effect on mescaline-induced psychosis in all 12 subjects, though the effect varied greatly among individuals. The relief was transient and did not substantially shorten the total duration of mescaline's effects. The most plausible explanation is that succinate provides an alternative substrate for oxidation in brain tissues when mescaline has depressed the oxidation of other substrates like glucose, lactate, and pyruvate.