Action of a chronic administration of mescaline in dynamic behavioural situations
Progress in Neuro-Psychopharmacology and Biological Psychiatry January 1, 1986 A Fundarò, L Molinengo, M.c. Cassone et al. 4 citations
Rats given daily mescaline (4 or 10 mg/kg) showed no impairment in adapting their behavior when the schedule of food reinforcement changed from a fixed ratio to a fixed interval. However, in a reversal test where the rewarded lever was switched, chronic administration of 4 mg/kg/day made rats completely unable to switch to the newly reinforced lever. A higher dose of 9 mg/kg/day had an excitatory effect, causing rats to make more reinforced responses than unreinforced ones during the second and third reversals, exceeding the control group's performance.