Regional localization of [14C]mescaline in rabbit brain after intraventricular administration
Neurochemical Research June 1, 1977 Nandkumar S. Shah, O. D. Dulati, D. A. Powell et al. 2 citations
After injecting radioactive mescaline into the lateral ventricle of anesthetized albino rabbits, the compound rapidly distributed across 12 brain regions, peaking within 15 minutes. Highest mescaline concentrations (23-57 nmol/g) appeared in the spinal cord, superior colliculus, pons, hypothalamus, caudate, medulla oblongata, and inferior colliculus; the cerebrum and hippocampus contained less than 10 nmol/g. Levels of both mescaline and its deaminated metabolite TMPA fell considerably by 180 minutes. Pretreatment with chlorpromazine lowered mescaline in limbic system areas (hippocampus, caudate, thalamus, cerebrum) and raised it elsewhere; iproniazid uniformly reduced TMPA and increased mescaline. The chlorpromazine effect on limbic regions may relate to its antihallucinogenic action in humans.