Comparison of Esketamine/Propofol and Sufentanil/Propofol on Intraoperative Hypoxemia During Bronchoscopy: A Randomized Trial.
Drug design, development and therapy January 1, 2025 Xiao Huang, Xueyang Li, Yuan Sun et al. 5 citations
In patients undergoing bronchoscopy, combining esketamine with propofol reduced the risk of dangerously low oxygen levels during the procedure compared with the standard combination of sufentanil and propofol. In a randomized trial, 27.2% of patients given esketamine experienced hypoxemia versus 66.7% given sufentanil. The esketamine group also had shorter episodes of low oxygen, higher minimum oxygen saturation, and faster recovery from anesthesia, though they required more propofol. Adverse reactions did not differ between groups. The authors suggest esketamine plus propofol may be a better option for preventing hypoxemia during bronchoscopy, but note that optimal dosing needs further study.