Comparison Between Esketamine and Alfentanil for Hysteroscopy: A Prospective, Double-Blind, Randomized Controlled Trial.
Drug design, development and therapy January 1, 2024 Mengcao Weng, Dongdong Wang, Jia Zhong et al. 17 citations
For hysteroscopy, the 95% effective dose (ED95) of esketamine combined with propofol was 0.254 mg/kg, while alfentanil's ED95 was 9.121 μg/kg. In a randomized trial, the anesthesia success rate with these ED95 doses was 93.0% for esketamine and 95.2% for alfentanil, with no significant difference. Induction time was shorter with esketamine (60 seconds) than alfentanil (67 seconds). Esketamine caused significantly lower rates of respiratory depression, hypoxia, and hypotension, and had less effect on breathing and blood pressure. Postoperative pain did not differ between groups. Esketamine is an effective and safer alternative to alfentanil for hysteroscopic anesthesia.