THE PRESERVATION OF SUBSTANCE P BY LYSERGIC ACID DIETHYLAMIDE
British Journal of Pharmacology and Chemotherapy September 1, 1957 William A. Krivoy 23 citations
Lysergic acid diethylamide (LSD) enhances the response of guinea pig ileum to substance P, but not to histamine, and prevents substance P from being broken down by guinea pig brain extract, though not by chymotrypsin. Other substances tested—eserine, morphine, mescaline, chlorpromazine, ergometrine, strychnine, and 2-bromo-LSD—did not produce this effect. Oxytocin was not degraded by brain extract. The inhibitory effect of LSD on substance P destruction was counteracted by 2-bromo-LSD, suggesting a potential link to LSD's pharmacological actions.