Hydroxylation and N-demethylation of N,N-dimethyltryptamine
Cellular and Molecular Life Sciences June 1, 1959 Stephen Szára, J Axelrod 74 citations
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Stephen Szára
St. Elizabeths Hospital
2 papers in the library · 107 citations · publishing 1959-1966
Papers
Psychological Effects and Metabolism of N,N-diethyltryptamine in Man
Archives of General Psychiatry September 1, 1966 Stephen Szára 33 citations
A simple indole derivative, N,N-diethyltryptamine (DET), produces psychotogenic-like symptoms similar to LSD and mescaline. Its metabolism involves 6-hydroxylation, a pathway shared by other naturally occurring indoles like tryptamine, skatole, and melatonin. This raises the possibility that this enzyme system could be involved in spontaneously occurring psychoses. The study compared DET metabolism in ten chronic schizophrenic patients and ten normal volunteers after a 1 mg/kg intramuscular dose, aiming to correlate the rate of DET metabolism with its psychological effects in humans.