Effects of Esketamine Versus Remifentanil on Hemodynamics and Prognosis in Patients with Septic Shock Receiving Invasive Mechanical Ventilation: A Randomized Controlled Trial.
Drug design, development and therapy January 1, 2025 Yuting Li, Hongxiang Li, Feng Zhang et al. 3 citations
In patients with septic shock on mechanical ventilation, adding esketamine to propofol sedation, compared with adding remifentanil, may reduce the dose of norepinephrine needed to maintain blood pressure. The two sedation regimens produced similar pain scores, and there were no significant differences in heart rate, mean arterial pressure, or 28-day survival. Esketamine appears to be a safe option that helps stabilize hemodynamics in this critically ill population.