In patients with septic shock on mechanical ventilation, adding esketamine to propofol sedation, compared with adding remifentanil, may reduce the dose of norepinephrine needed to maintain blood pressure. The two sedation regimens produced similar pain scores, and there were no significant differences in heart rate, mean arterial pressure, or 28-day survival. Esketamine appears to be a safe option that helps stabilize hemodynamics in this critically ill population.
LSD activates the TrkB signaling pathway in human neural stem cells (NSCs) similarly to the growth factor BDNF, but unlike BDNF, LSD does not promote NSC proliferation. This suggests LSD may activate an alternative mechanism that counteracts BDNF-TrkB signaling in NSCs, revealing a previously unrecognized cell type-specificity of LSD. The finding may deepen understanding of how LSD produces fast and persistent effects on anxiety and depression.