Drug-related suicidal ideation in the K-12 population: a real-world pharmacovigilance study of the FDA adverse event reporting system (FAERS) database.
Journal of psychiatric research August 1, 2025 Yaxin Ju, Yuan Liu, Li Tan et al. 3 citations
An analysis of the FDA Adverse Event Reporting System from 2004 to 2023 identified 21 drugs potentially linked to increased suicidal ideation risk in children aged 6–17. Among 4,779 valid cases, montelukast was the most commonly reported drug, and esketamine showed the highest statistical signal. The most common indications were ADHD, depression, acne, and asthma. Cumulative incidence of suicidal ideation within 90 days was 51.6% in males and 58.8% in females; within 360 days it was 76.9% and 85.3%, respectively. The findings suggest specific medications may pose elevated risk, but further research is needed to confirm.