Balanced Opioid-Free Anesthesia on Chronic Postsurgical Pain After Video-Assisted Thoracoscopic Surgery: A Randomized Controlled Trial Protocol.
Journal of pain research January 1, 2025 Wen-Wen Huo, Jia-Yu Qian, Han-Xue Zhao et al. 4 citations
Opioid-free anesthesia (OFA) combining dexmedetomidine, esketamine, and sevoflurane is being compared with opioid-based anesthesia (OBA) using sufentanil and sevoflurane in a randomized trial of 180 adults undergoing video-assisted thoracoscopic surgery lung resection. The primary outcome is the incidence of chronic postsurgical pain at 3 months. Secondary outcomes include acute pain, pain at 1 and 6 months, opioid consumption, adverse events, and quality of recovery. The hypothesis is that OFA will lower chronic pain rates, reduce adverse events, and improve recovery.