Beyond the toad's kiss: Mapping acute 5-MeO-DMT effects on brain connectivity across sex and dose using awake rat neuroimaging
Neuropharmacology March 6, 2026 Noah Cavallaro, Priya Rai, David Akins et al. 1 citation
In a first-ever fMRI study of 5-MeO-DMT, a fast-acting psychedelic, brain activity changes were observed that match its quick onset and short peak effects. A previously unknown sex difference in how the brain responds to the drug was also identified. The findings align with the drug's unique pharmacology and clinical reports, offering new insights into its neural effects.