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Sian Lewis

The Nature Conservancy

2 papers in the library · publishing 2025-2026

Papers

Psilocybin shapes neural plasticity in selective brain networks

Nature reviews. Neuroscience January 6, 2026 Sian Lewis

Psilocybin may enhance neuroplasticity, with a study involving 100 participants showing a 30% improvement in cognitive flexibility after treatment. This psychedelic compound influences neural activity, promoting connections in the brain akin to artificial neural networks. Participants reported heightened creativity and problem-solving abilities, suggesting potential applications in neuroscience and psychology. The findings align with emerging insights in cannabis and cannabinoid research, highlighting how psychedelics can reshape our understanding of biological systems and mental health therapies, paving the way for innovative therapeutic approaches.

‘Magic’ mechanisms underlie psilocybin’s effects in chronic pain

Nature reviews. Neuroscience November 11, 2025 Sian Lewis

Chronic pain affects approximately 20% of adults, significantly impacting quality of life and leading to high healthcare costs. In a study with 300 participants, 70% reported anxiety or depression alongside their pain. Interestingly, those receiving placebo treatments experienced a 30% reduction in pain levels, highlighting the powerful role of expectation in pain management. Additionally, advancements in psychedelics show promise for treating chronic disease-related anxiety and hyperalgesia, offering new avenues for physical medicine and rehabilitation in addressing these complex conditions.