THE EFFECT OF PSILOCYBIN AND EUGENOL ON LIPOPOLYSACCHARIDE INDUCED INFLAMMATION IN SMALL AND LARGE INTESTINE OF MICE
Zenodo (CERN European Organization for Nuclear Research) March 1, 2026 Zeinab Asghari, Gregory Robinson, Marta Gerasymchuk, Esmaeel Ghasemi Gojani, Timur Zanikov, Yasaman Rastamian, Olga Kovalchuk, Igor Kovalchuk*
Intestinal inflammation arises from immune dysfunction, epithelial abnormalities, and gut microbiota imbalances, contributing to conditions like irritable bowel disease and depression. In a study using lipopolysaccharide (LPS) to induce systemic intestinal inflammation in tissue, LPS caused greater inflammation in the large intestine than in the small intestine. Psilocybin reduced inflammation in the large intestine when given either before or after LPS, but in the small intestine it worked only when given after LPS. Eugenol reduced inflammation only when applied after LPS in both tissues.