Effects of psilocybin and related compounds on cerebroprotection during ischemic stroke (Stage 1 Registered Report)
November 17, 2025 Ruslan Rust
Psilocybin and related tryptamine compounds may protect brain cells after stroke by engaging serotonin receptor pathways. In this registered report, the authors plan to test these compounds using living brain slices from mice and human surgical tissue exposed to low oxygen and glucose to mimic stroke. They will measure cell survival and use single-nucleus RNA sequencing to identify which neuronal and glial cell types respond and which biological pathways are involved. The work aims to clarify the molecular and cellular mechanisms underlying potential cerebroprotection and may inform future psilocybin-based therapies for stroke.