davidbohnert/Predicting-LSD-induced-Subjective-Experience: Original Submission Version
Zenodo (CERN European Organization for Nuclear Research) December 31, 2025 David Bohnert
A connectome-based predictive model can predict the intensity of subjective experiences induced by LSD from patterns of brain connectivity measured before drug administration. The model was trained on resting-state functional MRI data and self-reported experience ratings from participants. It successfully predicted individual differences in the subjective effects of LSD, suggesting that pre-drug brain network organization carries information about how strongly a person will respond to the psychedelic.