Effective doses of esketamine oral or esketamine intranasal for the prevention of preoperative anxiety in pediatric patients: A randomized double-blind dose-finding trial
Medicine March 6, 2026 Hongfei Xiong, Yingxue Xu, Jiayi Liu et al.
Single-dose esketamine, given orally or intranasally, effectively reduces preoperative anxiety in children. The 95% effective dose (ED95) for oral administration is 8.2125 mg/kg (95% CI: 7.4250-8.4597 mg/kg), and for intranasal administration is 2.1770 mg/kg (95% CI: 2.0952-2.1958 mg/kg). The findings indicate both safety and efficacy for this use.