MDMA no tratamento de Transtornos Depressivos: revisão sistemática
Revista Neurociências September 25, 2025 Vinícius Nascimento Cavalcante Da Silva, Gisele Ferreira de Freitas, Julia Martins de Lima Moscatelli et al.
MDMA, administered in controlled doses (75mg to 180mg) during supervised sessions, significantly reduces depressive symptoms, even in cases resistant to conventional treatments. Therapeutic effects include rapid mood improvement, increased empathy, and reduced emotional isolation, with benefits sustained for months. Adverse events, such as tachycardia and nausea, were mild and transient. These findings suggest MDMA is a viable alternative for treating depressive disorder, especially refractory cases, though further studies are needed to validate its efficacy, safety, and clinical feasibility, and to overcome regulatory and logistical challenges.