Correlations between major depressive disorder, splenic morphology, and immune function.
BMC psychiatry May 12, 2025 Zouqing Lin, Xiaoyan Xu, Kai Zhang et al. 3 citations
Patients with first-episode or recurrent major depressive disorder (MDD) had higher levels of plasma MICB and larger splenic volume compared to healthy controls matched for age and gender. A positive correlation existed between MICB and splenic volume in the patient group. After treatment with (S)-ketamine, both elevated splenic volume and MICB levels decreased, suggesting that abnormal MICB expression and splenic morphology may be involved in MDD pathogenesis and that (S)-ketamine may reduce inflammation and improve splenic function.