World psychiatry : official journal of the World Psychiatric Association (WPA)
June 1, 2024
Dan J Stein, Kris Nielsen, Anna Hartford et al.
70 citations
Psychiatric understanding and treatment benefit from integrating both objective facts and subjective values, moving beyond strict scientism toward a softer naturalism. A pluralist approach—embracing ontological, explanatory, and value pluralism—acknowledges the multi-level causal interactions underlying psychopathology and highlights the importance of lived experience and diverse difference-makers in research and practice. Embodied, embedded, and enactive views of the brain-mind offer a conceptual framework for the mind-body problem that clinically integrates cognitive-affective neuroscience with phenomenological psychopathology.
Acta Neuropsychiatrica
February 13, 2026
Tanya Calvey, D. Govender, Gavin Owen et al.
Ibogaine, a psychedelic alkaloid with no approved medical use, has been linked in observational studies to symptom relief for substance use disorder, multiple sclerosis, and traumatic brain injury after a single dose. This review examines the neurobiological mechanisms behind these effects, focusing on remyelination and metabolic restoration. Evidence indicates ibogaine increases markers of myelination after opioid administration, and that these disorders involve white matter pathology and disrupted metabolic homeostasis, ischemia, and hypoxia. The authors conclude that ibogaine's multi-receptor actions—particularly on NMDA, kappa opioid, and sigma receptors—reduce excitotoxicity, regulate metabolism, promote lasting neuroplasticity, and modulate immunity, facilitating neuronal repair and remyelination, supporting further research as a therapeutic agent for these central nervous system disorders.