Active Metabolite of Aeruginascin (4-Hydroxy-N,N,N-trimethyltryptamine): Synthesis, Structure, and Serotonergic Binding Affinity
ACS Omega July 2, 2020 A.r. Chadeayne, Duyen N. K. Pham, Brian G. Reid et al. 31 citations
Aeruginascin, a naturally occurring tryptamine found in magic mushrooms, is thought to produce its effects through an active metabolite. This metabolite was synthesized and its structure confirmed. Competitive radioligand binding assays showed it binds with high affinity to human serotonin receptors 5-HT1A, 5-HT2A, and 5-HT2B, but does not bind to the 5-HT3 receptor, contrary to earlier predictions.