Treatment Expectancies and Psilocybin vs Escitalopram for Depression
JAMA Psychiatry December 10, 2024 Ethan G. Dutcher, Andrew D. Krystal 5 citations
People with major depressive disorder who had higher expectations for psilocybin treatment showed greater reductions in depression symptoms compared to those taking escitalopram, while expectations for escitalopram did not predict outcomes. The analysis used data from a randomized clinical trial and suggests that treatment expectancies may influence the relative effectiveness of psilocybin versus a standard antidepressant.