The Role of microRNA in Anaesthetics-induced Brain Injury: A Narrative Review.
Turkish journal of anaesthesiology and reanimation May 8, 2025 Elvan Öçmen, Bilge Karaçiçek, Burak İbrahim Arıöz et al.
Exposure to anaesthetic agents during late pregnancy or early childhood may damage developing brains. This review summarizes research on how microRNAs (miRNAs) regulate brain responses to anaesthetics. A systematic PubMed search identified studies on sevoflurane, isoflurane, ketamine, and propofol. Many miRNAs were found to have roles in both protecting and harming brain cells under anaesthesia. The evidence suggests miRNAs are crucial in anaesthesia-induced neurotoxicity, but their exact functions remain unclear. Further basic, clinical, and translational research is needed to clarify how miRNAs contribute to this process.