Self-Reported Efficacy of Treatments in Cluster Headache: a Systematic Review of Survey Studies
Current Pain and Headache Reports June 27, 2022 Sakari Santeri Rusanen, Suchetana De, Emmanuelle A. D. Schindler et al. 12 citations
A systematic review of nine retrospective surveys involving 5,419 respondents found that oxygen and subcutaneous triptan injections were most often reported as effective abortive treatments for cluster headache, while psilocybin and lysergic acid diethylamide (LSD) were most commonly reported as effective prophylactic treatments. The reported efficacy of most substances was consistent across different surveys, and the order of efficacy generally agreed with clinical studies. The findings suggest that retrospective surveys can provide supporting information on treatment effects and generate hypotheses about novel therapies. The consistently reported efficacy of psilocybin and LSD in prophylactic treatment indicates a need for clinical studies.