Application of a Radioimmunoassay Screening Test for Detection and Management of Phencyclidine Intoxication
The Journal of Clinical Pharmacology August 9, 1980 Balkrishena Kaul, Bernard Davidow 3 citations
A radioimmunoassay procedure was developed to detect phencyclidine (PCP) intoxication. In 11 patients with symptoms including violent behavior, delusions, hallucinations, and agitation, serum PCP concentrations in five subjects ranged from 0.5 to 40 ng/ml. For laboratory confirmation, ascorbic acid should be administered after collecting the initial urine specimen; the first or second postacidification urine often identified PCP when the initial specimen was negative or questionable. Patients in emergency rooms with hallucinations and a history of marijuana use should be screened for PCP; if negative, other hallucinogens such as LSD, ketamine, mescaline, or psilocybin may be suspected.