Exploring the Effects of Psilocybin on Depression and the Mediating Role of the 5-HT2A Receptor: A Systematic Review
Acta Neuropsychiatrica September 3, 2025 Filipe Reis Teodoro Andrade, Tobias Buchborn, Gabriel Thalheimer et al. 3 citations
Psilocybin therapy shows substantial and rapid antidepressant effects, often after one or two sessions with psychological support, with improvements sustained for weeks or months in many cases. It is generally well-tolerated, with mild adverse effects such as anxiety during administration and transient headaches that are manageable in controlled settings. Psilocybin demonstrates promise as a novel treatment for depression, especially for individuals unresponsive to conventional antidepressants. Further research is needed to refine dosing, explore long-term effects, and understand its mechanisms of action.