The Behavioral and Neuroinflammatory Impact of Ketamine in a Murine Model of Depression and Liver Damage.
International journal of molecular sciences April 10, 2025 Mădălina Iuliana Mușat, Ana-Maria Ifrim-Predoi, Smaranda Ioana Mitran et al. 5 citations
Ketamine relieved anhedonia and anxiety-like behavior in mice with both depression and non-alcoholic fatty liver disease (NAFLD), regardless of liver damage. It improved sociability, especially in older mice, but did not improve memory in those with liver injury. Acute ketamine did not worsen liver damage but appeared to affect brain cell changes (astrogliosis and neuronal loss). The findings suggest ketamine's antidepressant effects persist even with liver disease, though responses vary by age.