Insights into psilocybin use among people with bipolar disorder: A thematic analysis of Reddit posts
Journal of Affective Disorders January 20, 2026 Laura Mills, Susan L. Rossell, Sean Carruthers
Psilocybin use among people with bipolar disorder is associated with both benefits and risks. Analysis of 354 Reddit posts and comments revealed four themes: mania, depression, mixed experiences, and broader perspectives. Some users reported reduced depression symptoms and shifts in perspective, but others described increased or new mania, psychosis, and worsened depression. The findings suggest that while psilocybin may help some individuals with bipolar disorder, it also carries potential for adverse mental health effects.